Insulin release is glucose anomeric specific in the human.

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Insulin release is glucose anomeric specific in the human.

The alpha-glucose anomer produces a greater insulin release than beta-glucose in various animal models. These glucose anomers were dissolved rapidly and administered intravenously to human volunteers at a high dose (0.5 g/kg) over a 3-min period or a low dose (3.5 g) over a 20-s period. Blood samples were obtained at frequent time intervals for measurement of whole blood glucose (ferricyanide),...

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Epigenetic programming of glucose-regulated insulin release.

Pancreatic β cells support glucose homeostasis with great precision by matching insulin release to the metabolic needs of the moment. Previous gene-expression analysis indicates that adult β cells not only produce cell-specific proteins, but also repress a small set of housekeeping genes - such as those encoding lactate dehydrogenase A (LDHA), solute transporter MCT1, and hexokinase 1 (HK1) - t...

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ژورنال

عنوان ژورنال: Journal of Clinical Investigation

سال: 1976

ISSN: 0021-9738

DOI: 10.1172/jci108351